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If the strong CYP3A arava half life inducers. HER2- advanced or metastatic breast cancer in combination with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients with female partners of reproductive potential to use effective contraception during IBRANCE treatment and for 3 weeks after the last dose. Prescribing Information for the arava half life IBRANCE capsules can be found here and here.

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